Sensitivity of Autonomic Ganglia to Hexamethonium
نویسندگان
چکیده
منابع مشابه
Intravenous hexamethonium sensitivity and responses to oral treatment.
This study represents an effort to distinguish between neurogenic and humoral vasoconstrictive factors in a representative group of hypertensive patients by the response to hexamethonium ganglionic blockade. The correlation between intravenous hexamethonium sensitivity and subsequent treatment response was also determined. O~NE of the most difficult problems in essential hypertension is to sele...
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The heart contains superficial cardiac nerves whose effects may be modulated by pericardial fluid bathing the epicardium. We tested this hypothesis in open-chest dogs anesthetized with secobarbital. Oxygenated normal Tyrode's solution (NT) or NT containing hexamethonium, a ganglionic blocker (500 microM), or tetrodotoxin, a blocker of axonal neurotransmission (5 microM, TTX), was instilled into...
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The positive inotropic action of hexainethoniuin in hypodynamic and freshly prepared papillary muscles of the cat and the hypodynamic heart-lung preparation of the dog has been demonstrated. Within certain limits, there exists a proportionality between the concentration of hexamethonium and the magnitude of the inotropic response. In both preparations results have been obtained which indicate t...
متن کاملNeuroaxonal dystrophy in the autonomic ganglia of aged rats.
Distinctive axonal abnormalities in selected sympathetic ganglia of male and female Sprague-Dawley and male Fischer 344 rats have been characterized as a function of increasing age. Dilated intraganglionic axons contained a variety of unusual subcellular organelles, including large numbers of compact or loosely aggregated tubulovesicular profiles, layered membranous loops, and collections of no...
متن کاملDifferential selectivity of cardiac neurons in separate intrathoracic autonomic ganglia.
Analyses of activity generated by neurons in middle cervical or stellate ganglia versus intrinsic cardiac ganglia were performed to determine how neurons in different intrathoracic ganglia, which are involved in cardiac regulation, interact. Discharges of 19% of intrathoracic extracardiac neurons and 32% of intrinsic cardiac neurons were related to cardiodynamics. Epicardial touch increased the...
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ژورنال
عنوان ژورنال: BMJ
سال: 1953
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4814.814